Malaria Research Group
Profile
Malaria research group (RG) focuses on research on malaria in a whole aspect including molecular biology, pathogenesis, immunology, and clinical. With the vision to develop science and technology to control malaria in agricultural community, our missions are to conduct advanced research on the molecular aspects and pathogenesis of malaria, develop science and technology to design protein-based malaria vaccine, develop diagnostic kit for malaria clinical predictor, and design therapy regiment for antimalaria resistant, and develop research collaboration on malaria control with national and international institutions.
Key Areas of Research
- Recombinant proteins for development of protein-based malaria vaccine
- Proteins responsible for malaria pathogenesis for development diagnostic kit for malaria clinical predictor
- Single nucleotide polymorphisms (SNPs) in antimalaria resistant
Group Member

Dr.rer.biol.hum. dr. Erma S, M.Si., GCert.AgHealthMed.
Dept. Parasitology
Faculty of Medicine, Universitas Jember
Indonesia

Rosita Dewi, MD., M.Biotech.
Dept. Histology
Faculty of Medicine, Universitas Jember
Indonesia

Sheilla Rachmania, MD., M.Biotech.
Dept. Histology
Faculty of Medicine, Universitas Jember
Indonesia

Irawan Fajar K, MD.,M.Sc., Internist.
Dept. Public Health Science
Faculty of Medicine, Universitas Jember
Indonesia

Nurfaizah Titisari., MD., M.Biomed.
Dept. Histology
Faculty of Medicine, Universitas Jember
Indonesia
Collabolator
Dr.med. Nicole Berens-Riha. MD., MSc.Epid.
Institute of Tropical Medicine, Antwerp
Belgium
Prof. Dr. Loeki Enggar Fitri, MD., M.Kes, SpParK.
Faculty of Medicine Universits Brawijaya,
Indonesia
Publication
- Var gene and PfEMP-1 Indonesian Plasmodium falciparum: Characteristic, Diversity and Binding Capacity, 2013, LAP Lambert Academic Publishing
- Buku Ajar Agromedicine, 2018, Jember University Press, Jember
- Penyakit Infeksi Parasit di Indonesia, 2019, Trans Info Media, Jakarta
- Vaksin Malaria: Perkembangan generasi vaksin, kandidat protein untuk vaksin dan tantangannya, 2020, Jember University Press, Jember
- Protein Kandidat Vaksin Malaria, 2022, Jember University Press, Jember
- Protein Blood-stage Plasmodium falciparum: Teknologi DNA Rekombinan dalam Pengembangan Vaksin Malaria, 2024, Jember University Press, Jember
E Sulistyaningsih, IA Putri, S Rachmania. 2025. Analysis of Microglia Morphology and Number in Wistar Rats Brain After CIDR1α-PfEMP1 Recombinant Protein Injection. Al-Kauniyah: Jurnal Biologi 18 (1), 182-190
LYW Sari, Erma Sulistyaningsih, Tri Agus Siswoyo, 2025. Interleukin-6 as an Indicator for Acute Toxicity of DBL2β-PfEMP1 Recombinant protein as a Peptide-based Malaria Vaccine Candidate. Jurnal ILMU DASAR (JID). 26 (1). https://jurnal.unej.ac.id/index.php/JID/article/view/48709
Erma Sulistyaningsih, I Dewa Ayu Ratna Dewanti, . 2024. IgG AND CD4+ Responses Post Immunization With Cidr1α-Pfemp1 Recombinant Protein. Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan. 18(2). https://ejournal.upnvj.ac.id/JPM/article/view/7658
Erma Sulistyaningsih, Irawan Fajar Kusuma, Sheilla Rachmania, Rosita Dewi, Sahrir Sillehu, . 2024. Specific Sequence Motif of Var Gene as Predictor of Malaria Outcome. Elkawnie: Journal of Islamic Science and Technology. 10 (1). https://jurnal.ar-raniry.ac.id/index.php/elkawnie/article/view/14808.
Erma Sulistyaningsih, NA Sa’diyah, IF Kusuma, R Dewi, S Rachmania. 2024. Increased of Spleen White Pulp Diameter Post Dbl2β-Pfemp1 Recombinant Protein Injection in Wistar Rats: Pre-Clinical Study for Malaria Vaccine Development. Jurnal Profesi Medika. Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan 18 (1), 51-57
Yunita Armiyanti, Bagus Hermansyah, dr. Erma Sulistyaningsih, Wiwien Sugih Utami, Ida Srisurani Wiji Astuti, . 2024. Correlation of Intestinal Protozoa Infection with the Nutritional Status of Toddlers Aged 12–59 Months in Jember Regency, East Java, Indonesia. Althea Medical Journal. 11(2). https://journal.fk.unpad.ac.id/index.php/amj/article/view/3191
Erma Sulistyaningsih, Ancah Caesarina Novi Marchianti, Wulandari, Endang S. P. 2024. Determinant factors of under-five years severely wasted children in rural and sub-urban areas of Indonesia. Journal of Education and Health Promotion. 13 (1). https://journals.lww.com/jehp/pages/articleviewer.aspx year=2024&issue=07110&article=00242&type=Fulttext
Erma Sulistyaningsih, Rosita Dewi, Sheilla Rachmania, Irawan Fajar Kusuma, Moh Iqbal Al Zaman, Dwi Ari Santi Putri. 2023. DBL2β-PfEMP1 Recombinant Protein Dose Effect on Inducing Humoral and Cellular Immune Responses in Wistar Rats: A Study on Malaria Vaccine Development. Journal of Hunan University Natural Sciences. 50(1 2).
https://www.apjtm.org/currentissue.asp?sabs=n
Erma Sulistyaningsih, Rosita Dewi, Sheilla Rachmania, Irawan Fajar Kusuma. Molecular Detection Challenges of Human Plasmodium Knowlesi Infection by Polymerase Chain Reaction and Sequencing. Journal of Biomedicine and Translational Research. 2023/9 (2): 55-60.
Erma Sulistyaningsih, Leersia Yusi Ratnawati, 2022. The Analysis Causes of Informed Consent in Supporting the Quality of Medical Record In Graha Hospital Medika Banyuwangi. International Journal of Innovative Science and Research Technology. 6(12). https://ijisrt.com/the-analysis-causes-of-informed-consent-in-supporting-the-quality-of-medical-record-in-graha-hospital-medika-banyuwangi
Irawan Fajar Kusuma, Erma Sulistyaningsih, Rosita Dewi, Dwi Ari Santi Putri. 2022. Total Leukocyte Count in Rattus norvegicus after Duffy Binding-Like 2β-Plasmodium falciparum Erythrocyte Membrane Protein 1 Recombinant Protein Injection: The way to a Peptide-based Malaria Vaccine Development. Biomolecular and Health Science Journal. 6(1).
Erma Sulistyaningsih, Rosita Dewi, Hairrudin, Nurul Istinaroh. 2022. Expression and in silico Analysis of CIDRα1 Recombinant Protein from Plasmodium Falciparum as a Malaria Subunit Vaccine Candidate. Trends in Sciences (Walailak Journal of Science and Technology). 19(23). https://tis.wu.ac.th/index.php/tis/article/view/1621
Erma Sulistyaningsih, Rosita Dewi, Renaldi Wibisono. 2022. Leukocyte and IgM Responses to Immunization with the CIDR1α-PfEMP1 Recombinant Protein in the Wistar Rat. Tropical Medicine and Infectious Disease. 7(222). https://www.mdpi.com/2414-6366/7/9/222
Kartika Senjarini, Erma Sulistyaningsih, Rike Oktarianti, Syubbanul Wathon, Lailly Nur Uswatul Hasanah, Dewi Masruroh, Ika Wahyuni, Antje Labes. 2022. Internal transcribed spacer 2 (ITS2) based molecular identification of malaria vectors from Bangsring Banyuwangi-Indonesia. Asia Pacific Journal of Molecular Biology and Biotechnology. 30(3).
Iis Rahmawati, Erma Sulistyaningsih, . 2022. UJI COBA MODEL PENDIDIKAN KARAKTER REMAJA BERBASIS KELUARGA DALAM UPAYA PENCEGAHAN PERILAKU SEKSUAL PRANIKAH DI WILAYAH PEDESAAN DAN PERKOTAAN KABUPATEN JEMBER. The International Journal of Health, Education and Social (IJHES). 5(6). https://doi.org/10.17762/pae.v58i1.1968
Iis Rahmawati, Erma Sulistyaningsih, . 2022. Character Education Model In Preventing Pre- Sexual Behavior In Rural And Urban Areas. The International Journal of Health, Education and Social (IJHES). 5(6). DOI: https://doi.org/10.1234/ijhes.v5i6.238
Anak Agung Istri Ratnadewi, Sheilla Rachmania, Erma Sulistyaningsih. 2021. Recombinant DBL2b-Pfemp1 of the Indonesian Plasmodium Falciparum Induces Immune Responses in Wistar Rats. Journal of Taibah University Medical Sciences. 16(3). https://doi.org/10.1016/j.jtumed.2020.12.007
Erma Sulistyaningsih, . 2021. Neurobehavioral performance of Indonesian farmers and its association with pesticide exposure: A cross-sectional study. Clinical Epidemiology and Global Health. 11(2). https://www.sciencedirect.com/science/article/pii/S2213398421000580
Sri Hernawati, Erma Sulistyaningsih, . 2021. Behavioral Factors Against Hepatitis A Incidence in Universal Jember with Lawrence Green Method. Health Nation. 5(1).
Tantut Susanto, Erma Sulistyaningsih, 2020. The Differenced of Characteristics of Contraceptive Method of Condom and Vasectomy: A Cross-sectional Study Among Married of Malein Indonesia. TMR Integrative Nursing. 4( 4 ). https://www.tmrliferes.com/article.html?J_num=18&a_id=1092
Sheilla Rachmania, Rosita Dewi, Anak Agung Istri Ratnadewi, Erma Sulistyaningsih, . 2020. Epitopes Prediction of PfEMP1-DBL2β Recombinant Protein from Indonesian Plasmodium falciparum Isolate for Malaria Vaccine Development. Medico-Legal Update: An International Journal. 20(4). http://www.medicolegalupdate.org/scripts/Final%20pre%20release%20MLU%20October-December_2020%20(2).pdf
Ancah Caesarina Novi Marchianti, Erma Sulistyaningsih, 2020. The Correlation between Bacteria and Parasite Patterns on Flies with Prevalence of Fly Vector-Borne Disease at the Market and the Landfill in Jember District, Indonesia. Medico Legal Update. 20(4). http://www.medicolegalupdate.org/issues.html
Erma Sulistyaningsih, Sri Hernawati. 2020. Formalin Levels in White Tofu Based on Distribution Channels And Time Storage in Jember Regency, 2019. WORLD JOURNAL OF ADVANCE HEALTHCARE RESEARCH. 4(5). https://www.wjahr.com/home/article_abstract/532
Erma Sulistyaningsih, Dwi Wahyuni, Joko Waluyo, D. Q. Yaswinda. 2019. Toxicity Effect of Granular Bioinsecticide Mixture of Betel Leaf (Piper betel) and Srikaya Seed (Annona squamosa). IOP Conference Series: Earth and Environmental Science. 243(012096). https://iopscience.iop.org/article/10.1088/1755-1315/243/1/012096
Rosita Dewi, Erma Sulistyaningsih, Anak Agung Istri Ratnadewi, Sheilla Rachmania, Widhi Dyah Sawitri. 2018. Cloning, Sequence Analysis, and Expression of CIDR1α-PfEMP1 from Indonesian Plasmodium Falciparum Isolate. Current Topics in Peptide and Protein Research. 19(-). http://www.researchtrends.net/tia/title_issue.asp?id=26&in=0&vn=19&type=3
Erma Sulistyaningsih, Aris Prasetyo, Fathul Hidayah. 2018. Cloning and Protein Structure Prediction of DBL2β-PfEMP1 Recombinant Protein from Indonesian Plasmodium falciparum Isolate. Current Topicsin Peptide and Protein Research. 19( – ) . http://www.researchtrends.net/tia/title_issue.asp?id=26&in=0&vn=19&type=3
Wuryanti Handayani, Anak Agung Istri Ratnadewi, Erma Sulistyaningsih, 2018. Prebiotic Potential of Xylooligosaccharides Derived from Cassava Dregs in Balb/c Mice Colon. Tropical Agricultural Science. 41(3). http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(3)%20Aug.%202018/08%20JTAS-1165-2017.pdf
Jauhar Firdaus, Achmad Subagio, Erma Sulistyaningsih, . 2018. Resistant Starch Modified Cassava Flour (MOCAF) Improves Insulin Resistance. Asian Journal of Clinical Nutrition. 10(1). https://scialert.net/qredirect.php?doi=ajcn.2018.32.36&linkid=pdf
Bagus Hermansyah, Erma Sulistyaningsih, Loeki Enggar Fitri, Hidayat Sujuti, Agustina Tri Endharti, Niniek Burhan, Didi Candradikusuma, Josef Sem Berth Tuda, Umar Zein. 2018. Sensitivity and Specificity of Nested PCR for Diagnosing Malaria: Cases in Several Areas of Indonesia. Journal of Tropical Life Science. 8(2). https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/968
Erma Sulistyaningsih, Aris Prasetyo, Rosita Dewi, Brenda D Romadhon, F Hidayah, I Palupi. 2018. Sequence analysis of DBL2β domain of vargene of Indonesian Plasmodium falciparum. IOP Conference Series: Earth and Environmental Science. 125(-). http://iopscience.iop.org/article/10.1088/1755-1315/125/1/012015/meta
Erma Sulistyaningsih, Talitha Yuni Amalia, Rizka Kartikasari. 2017. Antioxidant and Antimalarial Activity of Leea indica leaf extract against Malaria-mice Model. Journal of Applied Pharmaceutical Science. 7(12). http://www.japsonline.com/admin/php/uploads/2516_pdf.pdf
Wuryanti Handayani, Erma Sulistyaningsih, Anak Agung Istri Ratnadewi, Agung Budi Santoso. 2017. Application of Cassava Peel and Waste as Raw Materials for Xylooligosaccharide Production using Endoxylanase from Bacillus subtilis of Soil Termit Abdomen. Procedia Chemistry. 18 ( ). http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=-11
Erma Sulistyaningsih, Bagus Hermansyah, Loeki Enggar Fitri, Teguh Wahju Sardjono, Agustina Tri Endharti, Samsul Arifin, Niniek Budiarti, Didi Candradikusuma, Nicole Berens-Riha. 2017. Clinical features of severe malaria: Protective effect of mixed plasmodial malaria. Asian Pasific Journal of Tropical Biomedicine. 7 (1). http://dx.doi.org/10.1016/j.apjtb.2016.11.001
Erma Sulistyaningsih, Agustin Iskandar, Teguh Wahju Sardjono, Ummu DityaErliana, Widya Rahmawati, Didi Candradikusuma, Utama Budi Saputra, Eko Suhartono, Bambang Setiawan. 2016. Plasma Glutathione and Oxidized Glutathione Level, Glutathione/Oxidized Glutathione Ratio, and Albumin Concentration in Complicated and Uncomplicated Falciparum Malaria. Asian Pacific Journal of Tropical Biomedicine. 6 (8). http://www.sciencedirect.com/science/article/pii/S2221169115308911
Erma Sulistyaningsih, Loeki Enggar Fitri, Thomas Loescher, Nicole Berens-Riha. Diversity of the var gene family of Indonesian Plasmodium falciparum Isolates. Malaria Journal. 2013. 12:80.
Erma Sulistyaningsih, Loeki Enggar Fitri, Thomas Loescher, Nicole Berens-Riha, Diagnostic difficulties with Plasmodium knowlesi infection in humans. Emerging and Infectious Diseases. 2010. 16(6).
The 5th International Conference on Agromedicine and Tropical Diseases (ICATD 5). EFFECT OF HIGH DOSE DBL2-PfEMP1 RECOMBINANT PROTEIN ON WISTAR RATS LIVER’S STRUCTURE AND FUNCTION AS MALARIA VACCINE CANDIDATE, Jember, 1-2 Agustus 2024.
The 3rd Asia Pacific Workshop and Conference on Molecular Medicine. INJECTION OF DBL2β-PfEMP1 RECOMBINANT PROTEIN DID NOT AFFECT LIVER AND KIDNEY HISTOPATHOLOGICAL APPEARANCE IN WISTAR RATS: STUDY FOR MALARIA VACCINE DEVELOPMENT, Tainan, 24-27 Juni 2024.
The 6th International Conference on Multidisciplinary Approaches for Sustainable Rural Development (ICMA-SURE 2023). Farmer’s general health appearance and symptoms after chronic chemical substances exposure and PPE application, Purwokerto, 19-20 Oktober 2023
The 5th USIM International Health Virtual Conference (IHEC 2022), The challenge for controlling malaria in Covid-19 pandemic situation, Negeri Sembilan Malaysia, 13-14 September 2022.
The 4th International Conference on Medical and Health Sciences (ICHMS 2022), The optimum dose recombinant DBlb2-PfEMP1 Protein in inducing humoral immune response: In vivo study for malaria vaccine development, Surabaya, 27-28 Juli 2022
The 2nd Health Science International Conference (HESICON 2), Specific binding domain of PfEMP1 as malaria vaccine candidate, Banjarmasin, 9-10 November 2021
The 4th International Conference on Life Sciences and Biotechnology (ICOLIB 4), Var D like gene as a marker for malaria outcome, Jember, 15-16 November 2021
The 4th USIM International Health e-Conference in conjunction with the 3rd International Conference on Medicine and Health Sciences (ICMHS), The S-protein Point Mutations of SARS-CoV-2 in Indonesian Covid19 Patients, Kuala Lumpur, Malaysia, 16-17 Desember 2020
The 3rd International Conference on Agromedicine and Tropical Diseases (ICATD 3), The bacteria and parasite patterns if flies do not associated with the prevalence of fly vector-borne diseases at the dairy farm, Jember, 12-13 September 2020
The 3rd International Conference on Tropical Studies and Its Application (ICTROPS), The diversity of var genes in Plasmodium falciparum and its implication on the clinical symptom of malaria, Samarinda, 26-27 Agustus 2019
The 2nd International Conference on Medicine and Health Sciences (ICMHS), Purification and Sequence Analysis of CIDR1α-PfEMP1 Recombinant Protein from Indonesian Plasmodium falciparum Isolate, Jember, 30 November-1 Desember 2018
The 5th International Seminar, Congress and Workshop of Indonesian Protein Society 2018, Prediction of Protein Structure and its Function of
Recombinant DBL2β domain of Indonesian Plasmodium falciparum Makasar, 8-9 November 2018.
The 2nd International Conference on Agromedicine and Tropical Diseases (ICATD 2), Expression and Structure prediction of CIDR1α-PfEMP1 recombinant protein from Indonesian Plasmodium falciparum Isolate, Jember, 21-22 Oktober 2018
The 1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI), Sequence analysis of DBL2 betha domain of var gene of Indonesian Plasmodium falciparum, 15-18 November 2017, Medan, Indonesia
The 1st International Seminar on Biotechnology (ISB), Possible association of CIDR 1alpha domain of PfEMP1 from Indonesia Plasmodium falciparum isolate with malaria outcome, 7 Oktober 2017, Yogyakarta, Indonesia
Joint International Tropical Medicine Meeting (JITMM), Expression of specific sequence in Plasmodium falciparum DBL domain associated with severe malaria outcome, 2016, Bangkok, Thailand
Joint Meeting of German Society for Tropical Medicine and International Health (DTG) and German Society for Parasitology (DGP) – Jahres Tagung, DBL domain expression in Plasmodium falciparum from Indonesia, 2012, Heidelberg, Germany
7th European Congress on Tropical Medicine and International Health, Expression of variant surface antigens in Indonesian Isolates from severe and uncomplicated Plasmodium falciparum malaria patients, 2011, Barcelona, Spain.